Fnip2
WebOct 31, 2024 · FNIP2 gene expression significantly correlated with both FNIP1 and FLCN (Additional file 1: Fig. S3B) and we observed associations between the levels of FLCN expression and increased weight, BMI, fat mass, visceral fatness, waist and hip circumferences, DBP, and blood levels of glucose, leptin, and triglycerides; and … WebView FNIP2 mouse/human homology from Alliance Direct with: genes, location, sequences, associated human diseases
Fnip2
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WebNov 27, 2024 · FLCN-FNIP2 adopts an extended conformation with two pairs of heterodimerized domains. The Longin domains heterodimerize and contact both nucleotide binding domains of the Rag heterodimer, while the DENN domains interact at the distal end of the structure. WebFolliculin has been identified as a negative regulator of rRNA synthesis in Drosophila and human cell lines ( Gaur et al., 2013 ). FLCN localizes in the nucleolus, where interacts …
WebT carriers of rs2291007 have decreased expression of FNIP2 in peripheral blood, and importantly, FNIP2 mRNA levels strongly associate with decreased obesity-related … WebThe putative FNIP2 LIR motif mapped to a >300-residue disordered loop within FLCN/FNIP2 from the LFC complex that was recently solved by cryo–electron microscopy (cryo-EM) …
WebComponent of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD … WebWe report here a mutation in the folliculin-interacting protein 2 (FNIP2) gene in the Weimaraner dog that results in hypomyelination of the brain and a tract-specific myelin defect in the spinal cord. This myelination disruption results in a notable tremor syndrome from which affected dogs recover with time.
Webin kidney, the Fnip2 expression level, which is commensurate with that of Fnip1, might maintain Fnip function in Fnip1-deficient kidneys, and therefore, double inactivation …
WebFNIP2 folliculin interacting protein 2 Gene ID: 57600, updated on 9-Mar-2024 Gene type: protein coding Also known as: FNIPL; MAPO1 See all available tests in GTR for this … dance theater nycWebAnti-FNIP2 antibody Description Rabbit polyclonal to FNIP2 Host species Rabbit Specificity ab106611 is predicted to not cross-react with FNIP1. Tested applications Suitable for: WB more details Species reactivity Reacts with: Rat Immunogen Synthetic peptide corresponding to 16 amino acids near the C terminal end of Human FNIP2 (NP_065891). dance theatre northwest rathdrumWebFeb 7, 2024 · Folliculin-interacting protein 1 and 2 (FNIP1 and FNIP2) play critical roles in preventing renal malignancy through their association with the tumor suppressor FLCN. Mutations in FLCN are associated with Birt-Hogg-Dubé (BHD) syndrome, a rare disorder with increased risk of renal cancer. bird with orange beak that is on beachWebZfish genes fnip2 Annotations are indicated with nodes colored by organism: Human , Mouse , Rat , Zfish Relations between GO terms are indicated by colored edges "is_a" ; "part_of" ; "regulates"; "positively_regulates" ; dance theater of harlem los angelesWebAug 31, 2024 · The lysosomal folliculin (FLCN) complex (LFC) consists of the inactive Rag dimer, the pentameric scaffold Ragulator, and the FLCN:FNIP2 (FLCN-interacting protein 2) GTPase activating protein... dance theater of harlem summer intensive 2023WebFNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss … dance theater of harlem schedule 2017bird with orange chest blue wings